Accession Number:

AD0606878

Title:

BASIC STUDIES IN PERCUTANEOUS ABSORPTION.

Descriptive Note:

Semi-annual rept. no. 7, Jan-Jun 64,

Corporate Author:

LEVER BROS CO EDGEWATER N J

Report Date:

1964-06-01

Pagination or Media Count:

200.0

Abstract:

Studies were continued along several lines regarding the nature and properties of the skin barrier. A better understanding of the relationships between temperature and relative humidity and degree of hydration of skin was gained. Also reported are the effects of organic solvents which can be divided into two classes one having a superficial effect of removing surface lipids and the other having a profound action of irreparably disrupting the barrier even without the physical removal of lipids. The activity of various lipids in enhancing the skin barrier was investigated employing, in addition to the measurements of water diffusion rate, assays of the skin resistance to a primary irritant and of the penetration of nickel and tritiated water. Arachidonic acid was shown to be vital in restoring the skin barrier in EFA-deficient rats. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE