PREPARATION AND EVALUATION OF STAPHYLOCOCCAL ENTEROTOXOIDS
Annual progress rept. for 1 May 1963-1 Aug 1964
PFIZER (CHAS) AND CO INC BROOKLYN NY
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Thirty Staphylococcal enterotoxiods were prepared and evaluated in rhesus monkeys in a range finding study designed to compare toxicities, antibody response, and protection against intraveneous challenge with untreated Staphylococcal enterotoxin. The immunization schedule consisted of three subcutaneous injections of toxoid with adjuvant spaced at intervals of five weeks. Some toxicity emesis, diarrhea was observed with most of the toxid preparations following the first subcutaneous immunization injection. No toxic reactions followed the second and third immunization injections. Antibody titers, as measured by hemagglutination and gel-diffusion, were generally low after the first immunization injections. Many of the antibody titers rose sharply after the second and third injections. A number of the Staphylococcal enterotoxoid preparations provided excellent protection in monkeys against intravenous challenge with untreated Staphylococcal enterotoxin three weeks after the third and final immunization injections.