SYNAPTIC TRANSMISSION IN SYMPATHETIC GANGLIA.
Final rept. for 1 Jul 63-30 Jun 64,
CALIFORNIA UNIV BERKELEY
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The synaptic mechanisms in sympathetic ganglia and the ways in which low doses of atropine may act in the body were investigated. The results obtained support the contention that there is an adrenergic inhibitory synaptic mechanism operating in ganglia, in addition to the well known cholinergic one. The activation of this adrenergic mechanism by preganglionic impulses was found to be sensitive to blockade by atropine. Atropine can affect brain function, and has been shown in recent years to block specifically cholinergic effects at certain sites in the brain. Analyses of the effects of cholinergic agents and atropine on brain function should take into account the possibility that these effects are transpiring at postsynaptic sites which generate slow synaptic responses, of the types seen in sympathetic ganglia. Author