Accession Number:

AD0601838

Title:

SYNTHESIS OF STEREOSPECIFIC AMINOTHIOLS AS RADIOPROTECTIVE AGENTS.

Descriptive Note:

Interim progress rept., 1 Mar 63-1 Mar 64

Corporate Author:

CALIFORNIA UNIV SAN FRANCISCO MEDICAL CENTER

Personal Author(s):

• Craig,J. Cymerman

Report Date:

1964-03-01

Pagination or Media Count:

9.0

Abstract:

Trans-2-n-octylamino-cyclopentanthiol and trans-2n-decylamino-cyclopentanthiol were synthesized and submitted for testing. The preparation of cis- and trans-1amino-indane-2-thiol is in progress. Successful reduction methods were developed for the preparation of 2-methyl-4, 5-cyclopentano-thiazolidine and spiro-2, 2-cyclohexano-4, 5-cyclopentano-thiazolidine. The conversion of these two key compounds into the required cis-2-aminocyclopentanthiol is under examination. Author

Descriptors:

• *RADIOPROTECTIVE AGENTS
• *ORGANIC NITROGEN COMPOUNDS
• THIOLS
• SYNTHESIS(CHEMISTRY)
• NITROGEN HETEROCYCLIC COMPOUNDS
• SULFUR HETEROCYCLIC COMPOUNDS
• SPIRO COMPOUNDS
• CYCLOPENTANES
• CYCLOPENTENES
• STEREOCHEMISTRY

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE