SYNTHESIS OF STEREOSPECIFIC AMINOTHIOLS AS RADIOPROTECTIVE AGENTS.
Interim progress rept., 1 Mar 63-1 Mar 64
CALIFORNIA UNIV SAN FRANCISCO MEDICAL CENTER
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Trans-2-n-octylamino-cyclopentanthiol and trans-2n-decylamino-cyclopentanthiol were synthesized and submitted for testing. The preparation of cis- and trans-1amino-indane-2-thiol is in progress. Successful reduction methods were developed for the preparation of 2-methyl-4, 5-cyclopentano-thiazolidine and spiro-2, 2-cyclohexano-4, 5-cyclopentano-thiazolidine. The conversion of these two key compounds into the required cis-2-aminocyclopentanthiol is under examination. Author