NEUROPHYSIOLOGICAL STUDIES OF BEHAVIOUR.
Final technical rept., 1 Apr 63-31 Mar 64,
ROME UNIV (ITALY)
Pagination or Media Count:
The results of the investigation of 1 behavior and EEg modifications induced by anticholinergic drugs and their combination with amphetamine, 2 modifications of cortical evoked responses after administration of atropine and amphetamine, and 3 modifications of the responses evoked in subcortical structures during avoidance conditioning experiments in the monkey are summarized. Small doses of amphetamine given to animals previously treated with anticholinergic agents restored the conditioned responses while not modifying the EEG activity. The cholinolytic drugs potentiated the excitatory effects of amphetamine. Amphetamine, given to previously atropinized animals restored the stage of diminished amplitude of the cortical responses both in the somatic and visual areas, in spite of the absence of clear-cut EEG modifications. A method was devised for implanting multiple electrodes in deep structures of the brain of the monkey. The preliminary results obtained with the study of the responses evoked in these structures during avoidance conditioning experiments are reported.