STUDIES ON HOMOGRAFT ACCEPTANCE AND REJECTION.
Annual progress rept., 30 Jun 63-15 Jun 64.
PETER BENT BRIGHAM HOSPITAL BOSTON MASS
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The progress made in the past year in the diagnosis, prevention, and therapy of the rejection process in homgrafting of human kidneys is presented. In this period, sixteen kidney transplants were done. Three of these cases died. The regime in the management of these cases and the laboratory research studies done in conjunction with these cases are outlined and evaluated under the following subjects 1 The diagnosis, prevention, and treatment of the rejection phenomenon, 2 Selection of recipients and donors, 3 Studies on histocompatability, 4 Studies on lymphocytes in tissue culture, 5 Management of kidney transplant patients as outpatients, 6 Studies on anti-platelet antibodies, 7 Studies on the antigen-antibody mechanism of tissue rejection, 8 Characterization of cell surface antigens, 9 Studies on complement and its role in graft rejection, and 10 Morphologic studies on rejecting kidney homografts.