EFFECT OF PARTIAL HEPATECTOMY ON DNA SYNTHESIS AND MITOSIS IN HETEROTOPIC PARTIAL AUTOGRAFTS OF RAT LIVER.
NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF
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Functioning, heterotopic, partial hepatic autografts without portal blood supply were used to investigate factors controlling regeneration of liver after partial hepatectomy in rats. Following partial hepatectomy DNA synthesis and mitosis in grafts were virtually identical to that occurring in residual livers of the same animals. These results are consistent with a feedback mechanism controlling hepatocytic proliferation, active throughout the body and distributed through the systemic circulation blood-borne. The nature, origin, and manner of action of the feedback mediator are not indicated by this study. This study also confirms that portal blood and increased hepatic blood flow are unnecessary for proliferation of hepatocytes. Author