Accession Number:

AD0601331

Title:

PATHOPHYSIOLOGY OF PULMONIC TOXICITY IN RATS EXPOSED TO 100 PER CENT OXYGEN AT REDUCED PRESSURES,

Descriptive Note:

Corporate Author:

NAVAL AIR DEVELOPMENT CENTER JOHNSVILLE PA AVIATION MEDICAL ACCELERATION LAB

Personal Author(s):

Report Date:

1964-05-05

Pagination or Media Count:

85.0

Abstract:

A life support support system for exposing experimental animals to artificial atmospheres is described. This system was used to subject mature, male, Caesarean-delivered, albino rats to essentially 100 per cent oxygen at pressures of 725, 650, 550, and 250 mm Hg. The environmental variables of temperature, pressure, relative humidity, PCO2, and PO2 were controlled within certain desired limits. The purpose of the oxygen exposures was to determine the hazard to rats of breathing pure oxygen at pressures of less than one atmosphere, for prolonged time periods. After exposure the dead and surviving animals were examined grossly and microscopically for pulmonary damage. The survival time of rats appears to be inversely related to the oxygen partial pressure. Their survival time begins to be appreciably lengthened at a pressure lying somewhere between 550 and 650 mm Hg. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE