Accession Number:

AD0600941

Title:

PHARMACOLOGICAL STUDY ON CENTRAL SYNAPTICA SYSTEMS AFFECTING MOTOR FUNCTION.

Descriptive Note:

Annual progress rept., 1 May 63-30 Apt 64,

Corporate Author:

MISSISSIPPI UNIV JACKSON SCHOOL OF MEDICINE

Report Date:

1964-04-30

Pagination or Media Count:

5.0

Abstract:

The effects of the drug BZ, a centrally acting atropine-like substance, on the electroencephalograms of conscious dogs was used as the criteria in the study of this drug and the evaluation of its antagonists. The animals were injected intravenously with BZ, followed one hour later by injections of possible BZ antagonists. Pipradol Meratran and methylphenidate Ritalin were the only two out of eight compounds tested that were effective in reversing the effects of BZ. The atropine-like effects of BZ blocked the effects of pilocarpine to increased saliva secretion. BZ produced a mild hyperglycemia, similiar to that found in some isolated reports in the literature on the effects of atropine.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE