Accession Number:

AD0600594

Title:

STUDIES ON TOLERANCE TO PROLONGED DEEP HYPOTHERMIA.

Descriptive Note:

Corporate Author:

DUKE UNIV DURHAM N C SCHOOL OF MEDICINE

Report Date:

1963-10-01

Pagination or Media Count:

17.0

Abstract:

The advantages of hypothermia, below 10 C for two hours, induced and maintained by extracorporeal circulation of 200 minutes were compared to partial bypass of the same duration during normothermia. In the normothermic group 5 of 6 dogs lived. In the hypothermic group 6 of 15 dogs 40 per cent survived when perfused to the high flow of 55 cckgmin. Eleven of 15 dogs 73 per cent survived when the flow rate was reduced to 20 cckgmin when the temperature was below 10 C. Metabolic data showed that no severe acidosis was present postoperatively in any group, and especially in the low flow group. The mortality was due to postperfusion lung syndrome even when low pressure was maintained in the left auricular chamber during perfusion. These findings are discussed and justify the use of low flow hypothermia during long lasting perfusion. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE