Accession Number:

AD0600282

Title:

INVESTIGATION OF THE MECHANISM OF ACTION OF RYANODINE ON MAMMALIAN SKELETAL MUSCLE.

Descriptive Note:

Final rept. 1 Nov 6l-30 Apr 63,

Corporate Author:

MARYLAND UNIV BALTIMORE DENTAL SCHOOL

Personal Author(s):

• White,John I.

Report Date:

1964-05-08

Pagination or Media Count:

9.0

Abstract:

Efforts to isolate, from granule suspensions incubated with MG and ATP, a chemical substance capable of relaxing contracted muscle fibers were unsuccessful. Conditions were established under which ryanodine increased by a factor of two or more the time required for fiber bundles to relax after addition of calcium to the bath containing ATP, MG and granules.

Descriptors:

• ALKALOIDS
• SKELETAL MUSCLE RELAXANTS
• DRUGS
• BIOASSAY
• NEUROMUSCULAR TRANSMISSION
• CONTRACTION
• RELAXATION(PHYSIOLOGY)
• BODY FLUIDS
• PH FACTOR
• ADENOSINE PHOSPHATES
• ELECTROLYTES(PHYSIOLOGY)
• MAMMALS

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE