Accession Number:

AD0600260

Title:

THERAPEUTIC PROPERTIES OF BLOOD PLASMA IN THE THERAPY OF TOURNIQUET SHOCK.

Descriptive Note:

Progress rept. l Jan 63-30 Apr 64,

Corporate Author:

JEWISH HOSPITAL ST LOUIS MO

Personal Author(s):

Report Date:

1964-04-30

Pagination or Media Count:

1.0

Abstract:

A significant difference in therapeutic effectiveness was demonstrated in the treatment of rat tourniquet trauma between reconstituted lyophilized aged human plasma RLAP and other clinically used albumin containing protein electrolyte solutions Albumisol, Plasmanate, Agamma Human Serum. RLAP in this experimental system provides a much superior survival rate even though the degree of plasma volume expansion provided by the two types of solutions is the same as long as 4 hours after tourniquet release. Because recently collected human plasma allows no survival after this trauma when given in the same way, it is believed that something deleterious is removed from the fresh plasma or something beneficial is produced in it during aging. The bulk of evidence to this point supports the latter hypothesis. Five Cohn fractions I, II, IV-l, IV-4, V have been suspended in a sodium chloride, sodium bicarbonate solution and produced the same survival results achieved by the control plasma RLAP. Fraction III in the mixture is not required. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE