STUDIES ON THE NATURE OF THE ABNORMALITIES IN SOLUTE AND WATER EXCRETION IN ACUTE TUBULAR NECROSIS AND OTHER RENAL DISEASES.
Final rept., 1 Oct 62-30 Nov 63,
WASHINGTON UNIV ST LOUIS MO SCHOOL OF MEDICINE
Pagination or Media Count:
The functional capacity of diseased kidneys was studied by including intrinsic renal diseases in one kidney of dogs. Electrolyte transport capacity of membranes was measured for frog skin and the urinary bladder of the turtle. The functioning of the diseased and the control kidney in the dogs were measured simultaneously. In all types of renal disease, functional competence. Glomerular filtration rate GFR was uniformly decreased. The decrease in several tubular functions was proportional to the GFR decrease. These ratios suggest that the glomerulo-tubular balance is the same in deseased and normal kidneys. Glucose titration showed no greater splay in the diseased kidneys than in the controls. The sodium, chloride, bicarbonate, and water excretion were qualitatively similar, but the diseased kidney excreted a greater fraction of the filtered load of these substances. Electrolyte transport by isolated frog skin and turtle bladder indicate that the sodium pump could operate electrogenically. Adenosine triphosphate ATP levels were well maintained under anaerobic conditions. The direct source of the energy for the sodium pump might be a high energy intermediate rather than ATP.
- Medicine and Medical Research