ATTRACTIVENESS AND REPELLENCY OF MAN TO MOSQUITO BITES.
Annual progress rept. 1 Nov 65-15 Sep 66,
STANFORD RESEARCH INST MENLO PARK CA
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A study was conducted on the synthesis and evaluation of analogs of DEET N,N-diethyl-m-toluamide as topical repellents. Volatility of these analogs was the most important factor affecting their repellency to Aedes Aegypti. Studies on contact repellents were also initiated. Progress has been made in the purification of the attractants in human sweat. Amino acids present in sweat are not attractive to Aedes aegypti. Gas chromatography, thin-layer chromatography and column chromatography were used to separate and identify repellents present in the hydrocarbon fraction of human skin-surface lipids. When evaluated in the olfactometer, certain terminally unsaturated hydrocarbons are repellent to Aedes aegypti. Body emanations attractive to Aedes aegypti can be trapped by the use of activated charcoal. Isolation and identification of these substances will be undertaken. A survey of numerous individuals revealed that the sweat of some strongly attracted and the skin-surface lipids of others strongly repelled the mosquitoes.
- Medicine and Medical Research