A NEW SYNTHESIS FOR 6-FURFURYLAMINO-9-BETA-D-RIBOFURANOSYL PURINE (KINETIN RIBOSIDE)
FORT DETRICK FREDERICK MD
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Kinetin riboside is of interest in plant physiology as a mitotic stimulant and in the tissue culture of cancer cells for its unusual differential toxicity toward adult human fibroblasts in the presence of human carcinoma cells. Three multi-step methods for its synthesis have been reported. This report describes a simple two-step synthesis for kinetin riboside that, unlike the cited methods of preparation, utilizes intermediates that are readily available and requires only a fraction as much time and effort for completion. Authentic kinetin riboside and material prepared by this synthesis were subjected to a number of physical and chemical tests and the data thus obtained are compared.
- Organic Chemistry