THE DISTRIBUTION AND THE CHEMICAL FORMS OF 2-MERCAPTOETHYLGUANIDINE AND BIS(2-GUANIDOETHYL) DISULFIDE GIVEN ORALLY IN PROTECTIVE DOSES TO MICE.
Technical documentary rept.,
ALBERT EINSTEIN MEDICAL CENTER PHILADELPHIA PA
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The distribution and chemical forms of 2-mercaptoethylguanidine MEG and bis2-guanidoethyl disulfide GED were studied in the various tissues of 8- to 10-week-old C57B1 male mice 30 minutes after an oral protective dose of 400 mg.kg. of MEG-S35 and GED-S35. At 30 minutes after oral administration of MEG or GED, a significant amount of protective agent remained in the gastrointestinal tract. This accounts for some of the differences in LD5030 values for equal doses of protective agent by oral and intraperitoneal routes. MEG was absorbed from the intestines more rapidly than GED, and protective forms appeared in the tissues in higher concentrations after MEG. This explains the better protection provided by oral MEG as compared with oral GED. The difference in absorption rates of MEG and GED may be useful in controlling the speed of onset and the duration of protection by these agents in mice. Author
- Anatomy and Physiology