Accession Number:

AD0477587

Title:

REGULATION OF METABOLISM IN WORKING MUSCLE IN VIVO. I. CONCENTRATIONS OF SOME GLYCOLYTIC, TRICARBOXYLIC ACID CYCLE, AND AMINO ACID INTERMEDIATES IN INSECT FLIGHT MUSCLE DURING FLIGHT.

Descriptive Note:

Rept. for 1962-1964,

Corporate Author:

CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Report Date:

1965-11-01

Pagination or Media Count:

29.0

Abstract:

The concentrations of 28 metabolites were measured concurrently in the flight muscle of the blowfly Phormia regina after flight periods ranging from 5 sec to 1 hr. Measurements were taken at flight initiation and during continuous flight. Coincident-change measurements identical to the 100-fold increase in glycolytic flux at the initiation of flight provide a unique system to determine the steps that control in vivo glycolysis in transition from a resting tissue to one performing strenuous work. The sites of regulation demonstrated in this system were 1 the phosphorolysis of fructose-6-P, 2 the cleavage of trehalose, and 3 the phosphorolysis of glycogen. Additional controls at alpha-glycero-P and proline oxidation are postulated. Author

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE