Accession Number:

AD0466977

Title:

RADIATION EFFECTS ON RENAL ENLARGEMENT IN THE MOUSE,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CA

Personal Author(s):

Report Date:

1965-05-09

Pagination or Media Count:

8.0

Abstract:

Weanling female CF-1 mice were subjected to unilateral nephrectomy followed in 3 hours by doses of total body radiation of 500 and 600 r. Other groups received doses of 500, 600, and 1350 r to half the abdomen over the remaining kidney 3 hours following unilateral nephrectomy. The effects of these procedures on the renal weight and body weight were measured 3 weeks after surgery. Control kidneys increased 80 in weight while 1350 r applied locally to the abdomen limited the weight gain to 55, and total body exposure to 600 r to 53. When nephrectomy was not performed, the kidney increased 34 in weight due to animal growth. Local exposure of one kidney to 1350 r limited the weight gain of both equally to 20. When the results are considered on the basis of renal weight to body weight ratio RB, no significant changes were produced by irradiation. Nephrectomy alone brought the ratio of the remaining kidney from .64 to 95 and the irradiated groups attained from .93 to 1.0. When the animals are grouped according to weight gain, those gaining over 6 show no significant radiation effect on renal weight gain. It is concluded that radiation in these dose ranges has on measurable direct effect on renal weight gain at 3 weeks after nephrectomy, but acts by systemic means related to decreased food intake and poor general condition. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE