Accession Number:

AD0466883

Title:

REJECTION OF ALLOGENEIC SKIN GRAFTS AND PRODUCTION OF ISOHEMAGGLUTININS BY SENSITIZED MICE AFTER SUBLETHAL IRRADIATION.

Descriptive Note:

Technical rept.,

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CA

Personal Author(s):

Report Date:

1965-05-27

Pagination or Media Count:

10.0

Abstract:

Male B6D2F1 mice were sensitized by the following means 1 an allogeneic AHeJ skin graft 2 three s.c. injections of AHeJ spleen cells in Freunds complete adjuvant or 3 three i.p. njections of AHeJ spleen cells. One week after the last injection, mice from each group received 670 rad whole-body X radiation. Sera were obtained frequently for hemagglutinin assay, and the mice were grafted with AHeJ skin 30 days or 61 days after irradiation. In all groups the homograft response was significantly impaired 30 and 61 days after irradiation however, in groups 1 and 2 normal secondary hemagglutinin responses were noted. This asynchronous recovery of the hemagglutinin and homograft responses suggested that distinct cell populations were responsible for these two manifestations of immunologic reactivity. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE