Accession Number:

AD0466649

Title:

PULMONARY VENTILATION AND DIFFUSION IN SHOCK

Descriptive Note:

Annual rept., 1 Jun 1964-31 May 1965

Corporate Author:

BOSTON UNIV MA

Report Date:

1965-06-01

Pagination or Media Count:

32.0

Abstract:

The injection of gram negative endotoxin into the systemic venous system of dogs, generally causes a fall in lung compliance and a rise in resistance to airflow. These changes did not occur if the endotoxin was injected through the portal system. Heparin in average dosage was not effective in preventing the respiratory change. The diffusing capacity of the canine lung for carbon monoxide was generally diminished by systemic intravenous endotoxin and pulmonary capillary blood volume fell significantly. In humans, carbon monoxide increases with increasing lung volume due primarily to a rise in blood volume. The ratio of blood volume to lung volume does not change with increasing lung volume in normal subjects, and may provide a useful standard for the study of patients.

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE