Accession Number:

AD0462102

Title:

RESPONSES OF COLD- AND WARM-ADAPTED DOGS TO INFUSED NORADRENALIN AND ACUTE BODY COOLING.

Descriptive Note:

Final rept., Oct 63-Nov 64,

Corporate Author:

KENTUCKY UNIV LEXINGTON

Personal Author(s):

• Nagasaka, Tetsuo
• Carlson, Loren D.

Report Date:

1965-02-01

Pagination or Media Count:

10.0

Abstract:

A total of 12 experiments was done in coldadapted C-A and warm-adapted W-A beagle dogs, kept more than 40 days at -10 C and 28 C, respectively. The animals, anesthetized with pentobarbital sodium were paralyzed with Flaxedil 5 mgkghour and mechanically ventilated at 28-30 C. Oxygen consumption, heart rate and colonic, pinna and paw skin temperatures were measured continuously. The dogs were infused with noradrenalin for 20 minutes at 30 C and after 45 minutes of acute cold exposure to 5 C. At 28-30 C, basal oxygen consumption was higher in C-A dogs. Oxygen consumption of C-A dogs increased with a slight increase in the heart rate during the initial 18-20 minutes after body cooling and then decreased. In W-A dogs, oxygen consumption decreased continuously after acute cold exposure. Calorigenic effects of infused noradrenalin were consistent in C-A and W-A dogs at 30 and 5 C, but there was no difference between the increased amound of oxygen consumption from the initial levels in both groups. Noradrenalin caused an increase of the heart rate in W-A dogs at 30 and 5 C, with decrease or no change in C-A dogs. Colonic, pinna and paw skin temperatures were significantly higher in C-A than in W-A dogs. Noradrenalin caused an increase in the temperatures, but the effect of the drug was more prominent in W-A than in C-A animals at lower temperature. Author

Descriptors:

• *NOREPINEPHRINE
• PHARMACOLOGY
• ACCLIMATIZATION
• DOGS
• PULSE RATE
• ARTERIES
• COLD WEATHER TESTS
• METABOLISM
• SHIVERING
• BIOCHEMISTRY
• SENSITIVITY
• TROPICAL TESTS
• SKIN(ANATOMY)
• INTESTINES

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE