Accession Number:

AD0453399

Title:

RELATIONSHIP BETWEEN COMPOUND STRUCTURE AND INFECTIVITY EFFECT ON EEE VIRUS

Descriptive Note:

Technical manuscript

Corporate Author:

VICKERS-ARMSTRONGS (AIRCRAFT) LTD WEYBRIDGE (UNITED KINGDOM)

Personal Author(s):

Report Date:

1964-09-01

Pagination or Media Count:

15.0

Abstract:

A number of sulfhydryl -SH compounds and the nonsulfur analogs of some of these compounds were tested for their effect on the infectivity of partially purified eastern equine encephalitis virus during storage at 4 C. Thiourea was found to be the most effective stabilizer whereas urea and guanidine caused a loss of viral infectivity. Thiosemicarbazide and semicarbazide showed effects similar to those of thiourea and urea. Viral inactivation produced by p- chloromercuribenzoate, sodium thioglycollate, or sodium ascorbate could be prevented by thiourea. No correlation was found between the oxidation-reduction potential of virus suspensions containing the various compounds and the infectivity titer, or change in titer, of these suspensions. The presence of an -SH group in the molecule is not a requisite for stabilization glutamine and dipyridyl exhibited good stabilizing properties.

Subject Categories:

  • Microbiology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE