ROLE OF THE LYMPHATICS IN PATHOGENESIS OF ANTHRAX
VICKERS-ARMSTRONGS (AIRCRAFT) LTD WEYBRIDGE (UNITED KINGDOM)
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The present investigations were carried out 1 to gain more information on the role of the lymphatics in pathogenesis of anthrax, 2 to determine the extent of lymphatic participation on extravascular circulation of bacilli, 3 to test for the removal of spores from the lung epithelium into the lymphatics andor blood stream immediately after challenge or during the infectious process of the disease, and 4 to determine whether systemic anthrax might be detected earlier by observation of bacilli in the lymph than by observation of the blood. Anthrax was shown to be established by the intraperitoneal, intracutaneous, or gastrointestinal routes through the lymph nodes that drain the region of challenge. In animals challenged by aerosol, the bacilli enter the lymphatics from the lung and are passed to the blood. Thereafter there is little difference in the dynamics of infection among the methods of challenge.
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