Accession Number:

AD0450347

Title:

DNA SYNTHETIC RATES AND CHROMOSOME REPLICATION IN GENERATING MARROW CELLS,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CA

Personal Author(s):

• Alpen, E. L.
• Cranmore, D.

Report Date:

1964-08-31

Pagination or Media Count:

18.0

Abstract:

The normally dividing bone marrow cells of the domestic cat provede suitable material for the examination of DNA replication patterns in individual chromosomes. Autoradiographic studies of chromosomes labeled with tritiated thymidine indicate a direct relation of chromosome size to duration of DNA synthetic activity of the 10 hours of the S period studied. In this same period dividing cells achieved a maximum labeling of 80. This suggests that a portion of the normally dividing cell population undergoes an arrest of considerable length in the G2 period. Author

Descriptors:

• CELLS(BIOLOGY)
• CHROMOSOMES
• BONE MARROW
• CATS
• DEOXYRIBONUCLEIC ACIDS
• TRITIATED COMPOUNDS
• AUTORADIOGRAPHY
• TRACER STUDIES
• SYNTHESIS
• METABOLISM
• LABELED SUBSTANCES
• DISTRIBUTORS

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE