Accession Number:

AD0445218

Title:

THE EFFECT OF VASOACTIVE ANTAGONISTS IN ENDOTOXIN SHOCK

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s):

Report Date:

1963-08-07

Pagination or Media Count:

18.0

Abstract:

The effect of pharmacologic antagonists on vasculare pressures in the perfused splenic artery, a branch of the portal vein, and in a systemic artery were monitored for 30 minutes after the injection of an LD50 of Shigella flexneri endotoxin. In control animals the injection of endotoxin was followed by a rapid increase in splenic arterial pressure, portal venous pressure, and vascular resistance across the spleen. Systemic arterial pressure exhibited an abrupt decline after the injection of endotoxin.

Subject Categories:

  • Toxicology
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE