Accession Number:

AD0440362

Title:

A COMPARISON OF THE ANALGETIC POTENCIES OF MORPHINE, PENTAZOCINE, AND A MIXTURE OF METHAMPHETAMINE AND PENTAZOCINE IN THE RAT,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s):

• Evans, Wayne O.
• Bergner, Donald P.

Report Date:

1964-02-27

Pagination or Media Count:

7.0

Abstract:

These studies were done to determine if the flinch-jump animal analgesiometric method could detect the analgetic effects of pentazocine. Also, to determine if a synergism of analgetic activity could be produced by adding methamphetamine to pentazocine. The flinch-jump procedure showed pentazocine to be an analgesic with a potency about one-third to one-quarter as great as morphine. Methamphetamine in combination with pentazocine raised the potency by a synergistic action. It was suggested that the combination of methamphetamine and pentazocine might have the following properties 1 non-addicting, 2 a good analgetic potency, 3 little autonomic depression, and 4 no sedation. Author

Descriptors:

• *ANALGESICS
• ANTIPYRETICS
• RATS
• MORPHINE
• AMPHETAMINES
• PHARMACOLOGY
• PSYCHOLOGY
• BEHAVIOR
• AUTONOMIC NERVOUS SYSTEM

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE