Accession Number:

AD0434424

Title:

ENDOCRINE AND METABOLIC EFFECTS OF SHORT-DURATION HYPEROXIA

Descriptive Note:

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX

Report Date:

1964-02-01

Pagination or Media Count:

11.0

Abstract:

This investigation was concerned with the effects of breathing 100 oxygen by mask at 1 atmosphere ambient pressure for 4 hours on sympathoadrenal, adrenocortical, and metabolic functions in healthy human subjects. Control determinations were made on the same subjects on a separate occasion by having the subjects breathe room air by mask. Sympathoadrenal activity was appraised by means of urinary epinephrine and norepinephrine determinations adrenocortical activity was appraised by means of plasma cortisol and urinary 17-hydroxy corticosteroid determinations and metabolic appraisal was made by means of urinary creatinine, urea, uric acid, phosphate, potassium, and sodium. Evidence of hyperoxia-induced adrenocortical and sympathoadrenal depression was found -- plasma cortisol concentration, as well as catecholamine excretion, falling below the control levels. Urine volume also was relatively low, as were urinary sodium and phosphate values. Mask discomfort was shown to be an obscuring factor, since it acted oppositely to hyperoxia in many respects. Author

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE