INFECTIVITY AND ANTIGENICITY OF STREPTOMYCIN-DEPENDENT SALMONELLA TYPHOSA
ARMY BIOLOGICAL LABS FREDERICK MD
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A streptomycin-dependent mutant of Salmonella typhosa injected live in rabbits stimulated the production of 0 antibodies. Sera from these rabbits protected mice against challenge with virulent S. typhosa. Mutation to the dependent state did not result in loss of antigenicity. Streptomycin dependency of the mutant was demonstrated in vivo in the mouse. Antibiotic treated mice succumbed to challenge with dependent bacilli, apparently because of presence of lethal quantities of endotoxin produced by multiplication of the mutant in the presence of streptomycin.