Accession Number:

AD0432416

Title:

PRESENCE OF DONOR SPECIFIC GAMMA-GLOBULINS IN SERA OF ALLOGENEIC MOUSE RADIATION CHIMERAS,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s):

Report Date:

1964-02-02

Pagination or Media Count:

13.0

Abstract:

Young adult DBA2 mice received a single whole body X-ray exposure of 840 rad an otherwise lethal dose followed by an intravenous injection of 8 x 10 to the 6th bone marrow cells from normal C3H x DBA2F1 donors. Control groups included syngeneic isogenic chimeras, i.e., DBA2 mice which received 840 rad plus an injection of 8 x 10 to the 6th DBA2 marrow cells. Blood serum from these chimeras was collected at times up to 9 months postirradiation, and analysed for total gamma-globulin levels and for specific donor or host type gamma-globulin isoantigens. Marrow-donor type gamma-globulins Igal were found in the serum of the allogeneic chimeras at various times up to 9 months after irradiation. By contrast, the sera from the syngeneic chimeras were negative for Igal gammaglobulin, and showed high levels of Iga3 gammaglobulin, the DBA2 type. It was shown also that the allogeneic chimeras were specifically tolerant to appropriate skin homografts whereas, the syngeneic chimeras rejected both A-strain skin grafts and C3H x DBA2F1 skin grafts. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE