EXPERIMENTAL STUDIES OF THE EFFECT OF CALCIUM DEFICIENT DIET TO THE ARTERIAL WALL AND OTHER TISSUES WITH SPECIAL REFERENCE TO CEREBROVASCULAR DISEASES.
Final rept. no. 1, 1 June 62-31 May 63,
TOHUKU UNIV SENDAI (JAPAN)
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A long-period experimental study of the effect of calcium deficient diets on the arterial walls of albino rats was conducted as a fundamental experiment of the theory concluded from the epidemiological investigation of vascular lesions affecting central nervous system prevailing in the North-East Japanese main land. One hundred forty Wistar strain albino rats were grouped into ten and fed with control diet, mildly calcium deficient and highly calcium deficient diets. Calcium contents were 300 mg, 150 mg, later 100 mg and 50 mg per 100 g diets respectively. The effect on the development of the animals was marked in the highly calcium deficient group as low increase rate of body weight and high mortality in the early stage of the life. However, the animals preliminarly fed with the control diet seemed not markedly influenced with the low calcium diet. This tendency was also noted from the balance study of calcium. Resorption rate of calcium was much greater in earlier stage of growth and at the low calcium diet groups. Histological examination showed that the effect of the different diets was not marked at twelfth month of life. Author