Accession Number:

AD0432116

Title:

HETEROTOPIC PARTIAL AUTOTRANSPLANTATION OF RAT LIVER: TECHNIQUE AND DEMONSTRATION OF STRUCTURE AND FUNCTION OF THE GRAFT,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s):

Report Date:

1964-01-15

Pagination or Media Count:

52.0

Abstract:

Previous attempts to heterotopically autograft parts of liver were reviewed. This review suggested that both adequate bile drainage and adequate blood flow were necessary for successful autografting of hepatic tissue. A two-stage procedure for subcutaneous autotransplantation of the median lobe of the rats liver by pedicle transfer was modified from Seneviratnes procedure. The modified technique, which separated the graft from the hepatic blood supply but preserved the bile drainage pathway, resulted in preservation of one-fourth to one-third of the mass of the median lobe with relatively normal structure and function for at least one year. This study demonstrated that hepatocytes in autografts could be maintained with normal relationship to bile ducts in the absence of portal blood, if collateral blood supply and biliary drainage were competent. Potential uses of partial autografts of liver for studying certain aspects of hepatic physiology were indicated. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE