Accession Number:

AD0431299

Title:

MECHANISMS OF ACTION OF THE INSECTICIDE ENDRIN

Descriptive Note:

Corporate Author:

FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROMEDICAL INST

Report Date:

1963-08-01

Pagination or Media Count:

21.0

Abstract:

Cardiovascular effects of endrin insecticide are obscure. Experiments to investigate these phenomena were carried out on dogs and suggested mechanisms of action have been proposed. Results show that acute administration of endrin produces bradycardia, hypertension, copious salivation, hyperexcitability, tonicclonic convulsions, increased body temperature, leukocytosis, hemoconcentration and decreased blood pH. Cerebral venous pressure and cerebrospinal fluid pressure elevations are also prominent features of endrin poisoning. Although most of these effects appear to be caused by endrin acting directly on the central nervous system some may result secondarily from altered cerebral hemodynamics.

Subject Categories:

  • Toxicology
  • Agricultural Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE