THE MECHANISM OF ACTION OF ENDOTOXIN
Rept. for 31 Oct 1962-31 Oct 1963
PITTSBURGH UNIV PA SCHOOL OF MEDICINE
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Evidence from this laboratory and others indicates that endotoxin shock is a form of anaphylactic shock mediated through natural antibody and characterized by complement-fixation in vivo that resistance to endotoxin shock can be increased by the acquisition of further antibody and that intestinal bacteria may influence susceptibility to endotoxin by their effect on the production of both natural and acquired antibody. The immunologic factors in the production of endotoxin shock were investigated further by the following studies 1 A Systematic Analysis of the Reaction Between Endotoxin and Complement 2 Immunization Against Bacteremic Shock by Feeding Viable E. coli 3 The Influence of Immunilogic Paralysis Induced by Mitomycin C on Susceptibility to Endotoxin and 4 A Comparison of the Toxic and Antigenic Properties of Endotoxin Purified by Density Gradient Zone Ultracentrifugation.