EXPERIMENTAL KETOSIS IN MAN. 'COLD KETOSIS' COMPARED WITH POST-EXERCISE KETOSIS AND NUTRITIONAL KETOSIS.
Annual progress rept. no. 2, 1 Oct 62-30 Sep 63,
ILLINOIS UNIV URBANA
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This investigation was designed to answer three questions 1 Does repetition of a ketosis following a 10 mile walk cause adaptive responses 2 Does repeated exposure to cold result in a diminished ketotic response 3 Do women show a post-exercise ketosis like men. Protocols for the three experiments were 1 Four subjects starved 2 days prior to and during a walk of 2.5 hours at 10 C and a rest thereafter of 11.5 hours at 25 C. During nine weeks, walks were conducted in weeks 1, 2, 3, 8, and 9, and not in the remaining four. 2 Four men were exposed nude to 0 C for 90 minutes once a week for 3 successive weeks. Comparable control studies were made at 25 C in a crossover pattern. 3 Three women walked outdoors for 2.5 hours at between 19 C and 27 C on three occasions, and then recovered for 5 hours. Men and women both displayed a decreasing ketotic response as a result of repetitive exposure to exercise and one out of four men showed a similar phenomenon with respect to adaptation to cold. Women displayed a post-exercise ketosis similar to that shown by men, despite much individual variability. Prolonged moderate exercise, exposure to cold and starvation all produce similar metabolic effects. Author