Accession Number:

AD0421848

Title:

CATECHOLAMINE RELEASE FROM ADRENAL SLICES AND RATE OF RESPIRATION,

Descriptive Note:

Corporate Author:

HARVARD MEDICAL SCHOOL BOSTON MASS

Personal Author(s):

Report Date:

1963-09-01

Pagination or Media Count:

8.0

Abstract:

The oxygen consumption of, and he catecholamine release from, incubated foul adrenal slices were studied under control conditions and during exposure to several chemical agents-i.e., potassium ion, reserpine, tyramine, and 2,4-dinitrophenol. Potassium ion, given as KC1, 0.1 M, and tyramine, 7.3 X 10 to the -3rd Power M, did not alter the respiration rate but did increase the rate of catecholamine release. Reserpine, 3.3 X 10 to the -5th power M, depressed the rate of respiration but did not affect the rate of release of catecholamines. 2,4-dinitrophenol, 7 X 10 to the -5th power M, caused as immediate, marked increase in oxygen consumption unaccompanied by any change in the rate of release of catecholamines over a period of 2 hours. Subsequently, the rate of release exceeded control values. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE