Accession Number:

AD0420322

Title:

THE ANTIDIURETIC PROPERTIES OF CHLOROTHIAZIDE IN DIABETES INSIPIDUS DOGS. I. EFFECT ON SOLUTE, WATER, AND ELECTROLYTE EXCRETION,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s):

Report Date:

1963-07-15

Pagination or Media Count:

27.0

Abstract:

Chlorothiazide decreased the urine volume and increased the urine concentration in diabetes insipidus dogs. The one consistent altered renal function was a decrease in free water clearance. There was no change in GFR, RPF, TmPAH, plasma volume extra-cellular fluid, and total body water. No evidence was found for any alteration in thirst or an ADH-like effect. Since mercuhydrin and diazoxide were not antidiuretic and salt blocked the antidiuretic response, it was felt that the antidiuresis is dependent upon the saluretic properties of chlorothiazide. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE