Accession Number:

AD0419978

Title:

STUDIES ON THE POTENTIATION OF EXDOTOXIN IN MICE BY EXPOSURE TO COLD

Descriptive Note:

Corporate Author:

BRYN MAWR COLL PA

Personal Author(s):

Report Date:

1963-05-01

Pagination or Media Count:

24.0

Abstract:

Mice exposed to 5 C show a drop in body temperature at a time when they are more sensitive than normal mice to bacterial lipopolysaccharide than LPS. Injection to 5 mg cortisone acetate protects against the lethal effects while 8 units but not 2 units of ACTH enhance lethality. These data suggest that adrenocortical exhaustion due to cold is in part responsible for the altered sensitivity of LPS. In support of this interpretation is the increase in urine volume and urinary nitrogen excreted by mice at 5 C compared with those of 25 C. Endotoxin decreses both. The decrease is counteracted by cortisone administration but not by ACTH.

Subject Categories:

  • Pharmacology
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE