Accession Number:

AD0419728

Title:

SOME METABOLIC EFFECTS OF METHIONINE TOXICITY IN THE RAT,

Descriptive Note:

Corporate Author:

ARCTIC AEROMEDICAL LAB FORT WAINWRIGHT ALASKA

Report Date:

1963-06-01

Pagination or Media Count:

9.0

Abstract:

Rats consuming a 15 casein diet containing 4.0 of DL methionine developed the following metabolic alterations in the liver increased activities of arginase, tryptophan pyrrolase, glutamic-oxalacetic and pyruvic transaminase, decreased levels of DPN and slightly increased levels of total and neutral fat. However, the fat content approached a normal level at the end of the tenth week of the experimental period. Urinary excretion of a number of amino acids was also markedly increased. Supplementation of the high methionine diet with 4.0 of glycine decreased the activity of arginase and the levels of some amino acids in the urine. The data indicate that ingestion of excess methionine leads to a disorder in nitrogen metabolism, and that the supplemented glycine diminishes these catabolic processes. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE