Accession Number:

AD0419658

Title:

THE INTERACTION OF ALDOSTERONE AND OTHER STEROIDS WITH LIVER AND KIDNEY CELL MEMBRANES AND WITH SUB CELLULAR FRACTIONS OF THE KIDNEY,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1963-05-21

Pagination or Media Count:

13.0

Abstract:

This report represents an investigation of the interaction of aldosterone with kidney and liver cell membranes and with kidney subcellular frac tions and to compare this interaction with that of other steroid hormones. Aldosterone is weakly bound to kidney subcellular fractions. Liver and kidney cell membranes were found to either take up the steroids tested according to their solu bility in lipids or to bind them in accordance with the polarity rule of steroid-protein inter action. Spirolactone failed to displace aldo sterone from the kidney cell membranes. The re sults indicate that none of the cell fractions investigated bind aldosterone strongly or preferentially. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE