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THE PROTECTIVE EFFECT OF DEEP BODY HYPOTHERMIA ON X-RAY INDUCED MITOTIC ABERRATIONS OF REGENERATING RAT LIVER,
NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF
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The protective effect of hypothermia against X ray induced mitotic aberrations of regenerating rat liver was studied. The mitotic index of con trol and irradiated animals was but little af fected by the hypothermic treatment, whereas the effect of X-rays on retarding growth body weight was reduced considerably by hypothermia. Furthermore, the number of X-ray induced mitotic aberrations in regenerating rat liver of hy pothermic irradiated rats was reduced to the con trol values. It was concluded that this latter effect was probable due to the extreme anoxic state rather than the concomitant hypothermia. Author
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