Accession Number:

AD0417590

Title:

STUDIES OF ADAPTATION OF PROTEIN MALNUTRITION.

Descriptive Note:

Annual progress rept., 1 Dec 62-30 Nov 63,

Corporate Author:

CALIFORNIA UNIV LOS ANGELES

Personal Author(s):

• Rubini,Milton E.

Report Date:

1963-11-30

Pagination or Media Count:

24.0

Abstract:

The rationale and technique of producing a static preparation of chronic protein malnutrition in rats and dogs is reported. The technique employs a period of fasting adjusted to initial weight of the animal and then titration to a low protein intake adequate in calories to maintain weight at 70-80 of initial weight. Such animals have been observed for over six months. They are normally active and appear well. Studies of such protein deficient animals include 1 Liver and intenstine mass strikingly reduced while bone growth progresses 2 Calcium is abosrbed more avidly and labile calcium pool is turned over more rapidly 3 Qualitative and quantitative changes occur in serum proteins with loss of alpha and beta globulins and relative increase in gamma globulins and 4 Granuloma formation is inhibited. Author

Descriptors:

• *PROTEINS
• NUTRITION
• ADAPTATION
• STARVATION
• LIVER
• INTESTINES
• CALCIUM
• DIET
• DOGS
• RATS
• ARMY RESEARCH

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE