Accession Number:

AD0416333

Title:

OBSERVATIONS ON ENERGY METABOLISM IN IRREVERSIBLE HEMORRHAGIC SHOCK.

Descriptive Note:

Annual progress rept., 1 Sep 55-31 Aug 63,

Corporate Author:

WISCONSIN UNIV-MADISON MEDICAL SCHOOL

Personal Author(s):

Report Date:

1963-09-07

Pagination or Media Count:

9.0

Abstract:

Two unusual mitochondria were isolated from dogs subjected to prolonged oligemic hypotension one from the liver appears to represent an adaptation to the abnormal physiological conditions imposed by the prolonged hypotension, the other, from the heart, seems to have sustained a permanent defect at the site concerned with ATP-synthesis. However, despite the presence of these abnormal mitochondria in the myocardium we have not yet succeeded in obtaining convincing evidence of any functional impairment of the heart as a whole. In both the dog and the rat the initial hemorrhage gives rise to a hyperglycemia, partly under adrenalin control. A peak concentration is reached at about the time of first reinfusion, after which a profound hypoglycemia is established which persists until death. In the rat survival appears somehow related to the maintenance of a hyperglycemic state. Despite persistantly elevated catecholamine levels in the circulating blood of our experimental dogs, the hearts at the time of death are severely depleted of norepinephrine. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE