Accession Number:

AD0415709

Title:

SITES OF INHIBITION OF BACTERIOPHAGE BY STREPTOMYCIN AND KCN,

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1963-05-01

Pagination or Media Count:

10.0

Abstract:

The penetration of T3 bacteriophages that are attached to the host cells may be delayed or entirely prevented by antiserum against T3 phage. The antiserum-sensitive period of the attached phages increases at lower temperatures and the degree of inhibition increases with antiserum concentration and with early exposure to anti serum. Bacteriophages T1 and T4 are not affected by antiserum in this manner T7 reacts similarly to T3. This phenomenon has been used to determine the time of action of several compounds that are known to inhibit phage replication at an early point in the infe process. Bacteriophages that have passed beyond their antiserum-sensitive stage in control experiments are held, in the presence of streptomycin, at a stage where they are sensitive to inhibition by antiserum. KCN allows the infectious process to proceed beyond the antiserum sensitive stage. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE