Accession Number:

AD0415208

Title:

THE PROTECTIVE EFFECTS OF PRETREATMENT WITH ADRENOCORTICOTROPHIC HORMONE IN TRAUMATIC SHOCK.

Descriptive Note:

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

Report Date:

1963-05-01

Pagination or Media Count:

3.0

Abstract:

Adrenocorticotrophic hormone ACTH was given to rats prior to subjecting them to a measured, severe, surfical trauma. Pretreated animals were able to maintain their systolic blood pressure at normal levels while untreated ani mals showed marked hypotension at the conclusion of the trauma. Animals which were stressed by being subjected to a cold environment 3 to 5 C for one week before trauma and pretreated with ACTH showed no difference in mean systolic blood pressure from untreated stressed controls. Pretreatment with ACTH has a definite vasopressor effect in previously eucorticoid animals. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE