THE PROTECTIVE EFFECTS OF PRETREATMENT WITH ADRENOCORTICOTROPHIC HORMONE IN TRAUMATIC SHOCK.
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
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Adrenocorticotrophic hormone ACTH was given to rats prior to subjecting them to a measured, severe, surfical trauma. Pretreated animals were able to maintain their systolic blood pressure at normal levels while untreated ani mals showed marked hypotension at the conclusion of the trauma. Animals which were stressed by being subjected to a cold environment 3 to 5 C for one week before trauma and pretreated with ACTH showed no difference in mean systolic blood pressure from untreated stressed controls. Pretreatment with ACTH has a definite vasopressor effect in previously eucorticoid animals. Author