Accession Number:

AD0415098

Title:

THE EFFECT OF CARBONIC ANHYDRASE INHIBITION IN EXERCISING RATS,

Descriptive Note:

Corporate Author:

FLORIDA UNIV GAINESVILLE

Report Date:

1963-05-01

Pagination or Media Count:

6.0

Abstract:

A series of experiments has been performed to ascertain the effect of carbonic anhydrase inhibition on the ability of rats to exercise in room air and in an atmosphere of 6 O2. In separate experiments, it was first established that peak plasma concentrations of the inhibitor acetazolamide after intraperitoneal injection and peak PCO2 values in subcutaneous gas pouches occurred concomitantly at about 60 minutes. Rats trained to run on treadmills were able to run as long as 5 12 to 6 hours at 0.46 mile per hour in room air whether carbonic anhydrase was inhibited or not. When exercised in 6 O2, however, the animals in which carbonic anhydrase was inhibited ran 39 longer, on the average, than did control animals. The increase in ventilation, which is known to be induced during carbonic anhydrase inhibition, without consequent tissue hypocapnia and alkalosis probably accounted for the improved exercise performance of inhibited animals in a low-oxygen environment. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE