THE EFFECT OF LIPASE INGESTION UPON BLOOD LIPID LEVELS.
Rept. for 20 Mar 62-5 Apr 63,
TEXAS UNIV DALLAS SOUTHWESTERN MEDICAL SCHOOL
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Supplements of a highly purified lipase were given with fat test meals to human subjects and dogs in order to determine the effect on blood lipid levels. The optical density and hence lipid levels of the blood plasmas were lowered in all subjects when sufficient lipase was ingested. The total esterified fatty acid and triglyceride determinations confirmed this measurement of the decrease acid and triglyceride determinations confirmed this measurement of the decrease in blood lipid levels. Human subjects with lowered fasting O.D. values and E.F.A. appeared to require more lipase to obtain this effect. The blood cholesterol values of normal subjects were not affected, nor was that of a hyperlipemic subject who ingested the lipase for over a four week test period. In all human subjects, the serum lipase values were elevated when the blood lipid levels were lowered. The association of elevated blood lipase levels with decreased blood lipids suggest the possibility of a lipolytic action in the blood. Author