Accession Number:

AD0412857

Title:

RESULTS OBTAINED TO DATE FROM A STUDY OF THE EFFECTS OF IONIZING IRRADIATION AND ITS EFFECT UPON FORMATION AND DEVELOPMENT OF THE HEALING WOUND.

Descriptive Note:

Final tt hnical rept., 1 Sep 61-31 Aug 62,

Corporate Author:

TEXAS UNIV SOUTHWESTERN MEDICAL SCHOOL AT DALLAS

Personal Author(s):

• Reynolds, B.L.

Report Date:

1962-08-31

Pagination or Media Count:

8.0

Abstract:

Chemical dd section of the period of recovery or relative energy gain during the healing of open skin wounds in animals has been investigated in detail in the past twelve months. Striated muscle, aerolar connective tissue, certain endocrine orgd4s, and the site of injury itself are the tissues titrated with respect to chemical changes during the process of edggdapproximation in healing. If exogenous total body irradiation of 1200 - 1500r be given at the optimum time during the recovery period, survival is increased from LD35 to 45 at 15 days. By use of improved analytical techniques the behavior of steroid substances, aromatic acids, fatty acids, amino acids, and sialic acids have been observed in each of the previously mentioned tissues. The gas chromatogram indicates the partition of active substances in the previously listed groups, and gives a means of estimating the amount of administered irradiation, the possibil ity of natural survival, and the areas where therapy may be of assistance.

Descriptors:

• *WOUNDS AND INJURIES
• *RADIATION EFFECTS
• RADIATION
• HEALING
• CHROMATOGRAPHIC ANALYSIS
• TISSUES(BIOLOGY)
• SURVIVAL(PERSONNEL)
• RECOVERY
• STEROIDS
• LETHAL DOSAGE
• METABOLISM
• WHOLE BODY IRRADIATION

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE