Accession Number:

AD0412355

Title:

STUDIES ON THE INTERRELATIONSHIP OF COLD ENVIRONMENT, IMMUNITY AND RESISTANCE TO INFECTION. I. QUALITATIVE AND QUANTITATIVE STUDIES ON THE IMMUNE RESPONSE,

Descriptive Note:

Corporate Author:

ARCTIC AEROMEDICAL LAB FORT WAINWRIGHT ALASKA

Personal Author(s):

Report Date:

1963-04-01

Pagination or Media Count:

26.0

Abstract:

Immunochemical studies have been conducted on sera from rabbits to investigate the quantita tive aspects of the immune response under condi tions of hypothermia. Rabbits have been sub jected to lowered environmental temperature 4 C, shaved of their pelage and immunized with various protein antigens. Serum samples obtained from varying periods during each of the studies via cardiac puncture have been qualitatively assayed for antibody response by Ouchterlony gel diffusion, immunoelectrophoresis, starch gel electrophoresis and paper electrophoresis. Quantitative analyses h included ring precipi tin titrations, quantitative gel diffusion analy sis and micro-quantitative precipitin analysis. In all of the studies the responses of the cold exposed animals have been compared with non-cold exposed animals treated in an identical manner except for maintenance at the lower environmental temperature. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE