EFFECTS OF DECABORANE ON BRAIN ACTIVITY
Rept. for 1 May 1962-25 Feb 1963
YALE UNIV NEW HAVEN CT
Pagination or Media Count:
The effects on intraperitoneal injection of decaborane have been investigated in monkeys with electrodes permanently implanted in the brain. One single injection of 5 mgkg produced a marked behavioral depression, with only moderate electroencephalographic modifications, followed by death in 18 hours. Four daily doses of 3 mgkg produced depression, somnolence, twitching in both arms, accompanied by bursts of high-voltage activity, localized in the internal capsule. Death occurred 3 days later. Daily doses of 1 mgkg up to a total of 14 mgkg pro produced depression, muscular twitching, anorexia, and a typical electroencephalographic pattern, but the animals recovered completely. Depression may be related to reticular system involvement. Motor symptomatology could depend on disturbances of heavily myelinated motor axons which may have a special affinity for the liposoluble decaborane. Hypothalamic involvement was questionable, but neighboring structures, especially the internal capsule showed electrical disturbances.
- Anatomy and Physiology