Accession Number:

AD0411769

Title:

EFFECTS OF DECABORANE ON BRAIN ACTIVITY

Descriptive Note:

Rept. for 1 May 1962-25 Feb 1963

Corporate Author:

YALE UNIV NEW HAVEN CT

Personal Author(s):

Report Date:

1963-05-01

Pagination or Media Count:

24.0

Abstract:

The effects on intraperitoneal injection of decaborane have been investigated in monkeys with electrodes permanently implanted in the brain. One single injection of 5 mgkg produced a marked behavioral depression, with only moderate electroencephalographic modifications, followed by death in 18 hours. Four daily doses of 3 mgkg produced depression, somnolence, twitching in both arms, accompanied by bursts of high-voltage activity, localized in the internal capsule. Death occurred 3 days later. Daily doses of 1 mgkg up to a total of 14 mgkg pro produced depression, muscular twitching, anorexia, and a typical electroencephalographic pattern, but the animals recovered completely. Depression may be related to reticular system involvement. Motor symptomatology could depend on disturbances of heavily myelinated motor axons which may have a special affinity for the liposoluble decaborane. Hypothalamic involvement was questionable, but neighboring structures, especially the internal capsule showed electrical disturbances.

Subject Categories:

  • Toxicology
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE