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Accession Number:
AD0410779
Title:
CARDIOVASCULAR EFFECTS OF NOREPINEPHRINE THERMO GENESIS IN WARM- AND COLD-ACCLIMATIZED RATS,
Descriptive Note:
Corporate Author:
ARCTIC AEROMEDICAL LAB FORT WAINWRIGHT ALASKA
Report Date:
1962-03-01
Pagination or Media Count:
1.0
Abstract:
The cardiovascular and metabolic actions of nore pinephrine NE and their interrelationships were studied at normal room temperature in anesthe tized, warm-acclimatized W-A 26 1 C and cold-acclimatized C-A 3 1 C rats. Norepine phrine caused a greater increase in the cardiac output, heart rate, stroke volume and right atri al pressure in the C-A animals than it did in the W-A animals. During the early metabolic response to NE i.e. up to 25 increase in O2 consumption there was a marked increase in the arterial pres sure of both W-A and C-A rats, with the latter showing the greater maximum response. Beyond the 25 level of increased metabolism the arterial pressure and concomitantly the systemic resistance of the C-A animals declined sharply to the prein fusion levels, where they remained throughout the course of infusion. In contrast, the arterial pressure and systemic resistance of the W-A animals remained high. It was concluded that norepinephrine calorigenesis in the C-A rat is supported by an increased cardiac reserve capacity and an ability to preferentially reduce the sys temic resistance to actively metabolizing areas. i.e. the viscera. Author
Distribution Statement:
APPROVED FOR PUBLIC RELEASE